Cytomel is the most common synthetic version of the T3 or triiodothyronine. T3 is not produced directly by the thyroid gland but by the thyroid-stimulating hormone
or THS. THS is also responsible for the production of T4 or thyroxine.
And lets make one thing clear, Cytomel is not a steroid, but more a of a cutting aid. It’s a synthetic form of the thyroid hormone tri-iodio-thyronine or T3,
made up of a metabolite of the amino acid tyrosine and 3 iodine ions.
Taking Cytomel (supplemental T3) greatly increases the uptake of nutrients into the mitochondria and also their oxidation rate (i.e. the rate at which they are
burned for energy), by increasing the activities of the enzymes involved in the oxidative metabolic pathway. Everything is working harder, in other words, and
more fuel is needed to supplement this increased work rate. Therefore, as you can guess, taking supplemental Cytomel will increase your bodys energy demands.
And if you are in a hypocaloric state, you will begin burning even fatter primarily due to an increase in ATP. This increased ATP causes an increase in overall
metabolic activity. (8)(9)This is exactly what we want, and is why we would be taking thyroid hormones like Cytomel in the first place. If you arent taking anabolic
steroids with your Cytomel, however, your body may start to eat away muscle to provide energy for you to function. Remember mitochondria/ATP arent very picky, but
they are very efficient. What I mean by this is that they will use whatever is on hand to generate energy for your body to continue functioning, fat, protein, glucose;
it doesnt matter to ATP, as long as theres something to give them energy. Taking this drug will increase their need to find something to burn to create this energy.
Ergo, if we arent taking anabolic steroids while taking our T3, we may lose too much muscle, especially while dieting.
Thus we can see that there are many advantages to using Cytomel to optimize our metabolic rate. It will also increase your bodys ability to synthesize protein, but
from what Ive seen personally, it acts as a catabolic when it isnt administered with anabolic steroids. It is often the last thing added into a precontest diet, as
it has a reputation for getting rid of the last few percentages of bodyfat& the “sticky fat” as its called in bodybuilding, the fat that just doesnt want to leave
you in the last few weeks of dieting. I think this is a poor use for this drug, and that it should be the first thing added into a diet to lose fat, as it will optimize
your metabolic rate, which should be done at the outset of a diet, not after the calorie restriction has diminished your thyroid output and you are adding it in simply
to replace what was lost.
As with insulin, misuse of this compound can leave you dependent on exogenous T3 for the rest of your life (remember Frank Zane?). So some caution and research
is required before putting Cytomel in your body. Generally cycles should be limited to 4-6 weeks tops, I recommend 3 and alternating cycles with 3-week cycles of
clenbuterol. But most importantly, to avoid a crash or a shock to the thyroid function doses need to be built up over time and tapered off again. More so for cytomel
than for any other drug in existence.