Anastrozole (Arimidex ) is the aromatase inhibitor of choice. Commonly athletes use 0.25 mg. to 1 mg. per day or 0.5 mg. to 1 mg. every other day.
Using moderate doses of testosterone 0.5 mg ARIMIDEX/day is usually sufficient and in some cases may be too much.
Arimidex, being an aromatase inhibitor, prevents gynecomastia and minimizes water retention and has also been proven to increase natural testosterone production.
The drug is appropriately used when one is prone to gynecomastia and using moderate amounts of steroids like testosterone. Arimidex does not have the side effects of
aminoglutethimide (Cytadren) and can achieve a high
degree of estrogen blockade, much moreso than Cytadren. It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably
salivary tests, should be taken after the first week of use to determine if the dosing is correct.
As an aromatase inhibitor, Arimidex’s mechanism of action — blocking conversion of aromatizable steroids to estrogen — is in contrast to the mechanism of action of
anti-estrogens such as clomiphene (Clomid) or tamoxifen (Nolvadex), which block estrogen receptors in some tissues, and activate estrogen receptors in others.
During a cycle, if using Arimidex, there is generally no need to use Clomid as well, but (as mentioned in the section on Clomid) there may still be benefits to doing so.
joint pain or stiffness;
depression, mood changes;
back pain, bone pain.